Welcome to our suite of eGFR (Estimated Glomerular Filtration Rate) calculators. eGFR is a key indicator of kidney function. Different formulas exist, each with its specific applications and variables. Choose a calculator below to assess kidney function based on various established equations.
| Equation | Access Calculator |
|---|---|
| 2021 CKD-EPI Creatinine | Go to Calculator |
| 2021 CKD-EPI Creatinine-Cystatin C | Go to Calculator |
| 2009 CKD-EPI Creatinine | Go to Calculator |
| 2012 CKD-EPI Cystatin C | Go to Calculator |
| 2012 CKD-EPI Creatinine-Cystatin C | Go to Calculator |
The CKD-EPI (creatinine) was developed by Levey et al in 2009, who measured GFR of 8,254 participants using clearance of iothalamate (the most recent recommended gold standard). Linear regression was used to estimate the logarithm of measured GFR from standardized creatinine levels, sex, race, and age.
The equation was validated by Inker et al (2012) and found to be more accurate than the MDRD Equation (percentage of estimated GFR within 30% of measured GFR was 84.1% vs. 80.6%). The sensitivity and specificity of estimated GFR <60 mL/min/1.73 m2 were 91% and 87%, respectively, using the CKD-EPI equation and 95% and 82%, respectively, using the MDRD Equation.
Debate has arisen regarding the use of the adjustment coefficient for black patients. Because of this, Inker et al (2021) updated the CKD-EPI formulae to redevelop the equation so that the race component was removed from the equation.