MARS Calculator

Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

Age, years

≤60 0

>60 +1

Hemoglobin

≥10 g/dL (≥6.2 mmol/L) 0

<10 g/dL (<6.2 mmol/L) +1

Platelets

≥100×10⁹/L 0

<100×10⁹/L +1

Presence of adverse mutations

(SRSF2, ASXL1, and/or RUNX1)

None 0

One mutation +1

Two or more mutations +2

MARS Score Result:

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Risk Categories

Low Risk (0-1 points): Median OS not reached

Intermediate Risk (2-3 points): Median OS 3.9 years

High Risk (≥4 points): Median OS 1.9 years

Clinical Information

MARS integrates clinical parameters with molecular genetics to predict overall survival in advanced systemic mastocytosis.

High-risk mutations: SRSF2, ASXL1, RUNX1

This calculator is for educational purposes only and should not replace professional medical advice. The MARS score should be interpreted by qualified hematologists familiar with systemic mastocytosis.