Duke Criteria for Infective Endocarditis

Duke 1994: definite if ≥2 major OR (1 major + ≥3 minor) OR ≥5 minor; possible if 1 major + 1 minor OR ≥3 minor; else rejected.

Major criteria

Blood cultures positive for typical organisms from two separate cultures, or persistently positive cultures Evidence of endocardial involvement: positive echocardiogram for vegetation, abscess, or new partial dehiscence of prosthetic valve, OR new valvular regurgitation Single positive blood culture or serologic evidence of active infection with organism consistent with IE but not meeting major #1

Minor criteria

Predisposing heart condition or injection drug use Fever ≥38.0°C (100.4°F) Vascular phenomenon (arterial emboli, septic pulmonary infarcts, mycotic aneurysm, etc.) Immunologic phenomenon (glomerulonephritis, Osler nodes, Roth spots, rheumatoid factor, etc.) Microbiologic evidence not meeting major criterion

Educational tool only—not for diagnosis or treatment decisions.

Duke Criteria for Infective Endocarditis

Calculator

Duke classification

How it works

Limits